Ca2+ channel blocker benidipine promotes coronary angiogenesis and reduces both left-ventricular diastolic stiffness and mortality in hypertensive rats
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چکیده
منابع مشابه
Increased passive stiffness promotes diastolic dysfunction despite improved Ca2+ handling during left ventricular concentric hypertrophy
Aims Concentric hypertrophy following pressure-overload is linked to preserved systolic function but impaired diastolic function, and is an important substrate for heart failure with preserved ejection fraction. While increased passive stiffness of the myocardium is a suggested mechanism underlying diastolic dysfunction in these hearts, the contribution of active diastolic Ca2+ cycling in cardi...
متن کاملRelation between aortic stiffness and left ventricular diastolic function in patients with hypertension, diabetes, or both.
OBJECTIVE To evaluate aortic function and its relation to left ventricular diastolic function in patients with hypertension, diabetes, or both, without coronary artery disease. METHODS Study groups were composed of 27 healthy participants and 25 patients with hypertension, 24 with diabetes, and 18 with hypertension and diabetes. Coronary artery disease was excluded in all of the study partici...
متن کاملLeft ventricular diastolic chamber stiffness and intramyocardial coronary capacitance in isolated dog hearts.
BACKGROUND Because the myocardium is perfused primarily during diastole, changes in diastolic properties of the left ventricle (LV) should influence the intramyocardial circulation. METHODS AND RESULTS We examined the influence of LV diastolic properties on the magnitude and localization of intramyocardial coronary capacitance by analyzing the coronary pressure-venous flow relation in isolate...
متن کاملArterial stiffness and left ventricular diastolic function: does sex matter?
Diastolic heart failure with preserved systolic ejection fraction is becoming a major health burden and is responsible for 50% of heart failure hospital admissions. Arterial hypertension is one of the most important risk factors for diastolic dysfunction; however, systolic and diastolic blood pressures are the 2 extreme points of the arterial waveform. Arterial stiffness/elasticity derived from...
متن کاملLeft ventricular diastolic function in essential hypertensive patients: influence of age and left ventricular geometry.
PURPOSE To evaluate diastolic dysfunction (DD) in essential hypertension and the influence of age and cardiac geometry on this parameter. METHODS Four hundred sixty essential hypertensive patients (HT) underwent Doppler echocardiography to obtain E/A wave ratio (E/A), atrial deceleration time (ADT), and isovolumetric relaxation time (IRT). All patients were grouped according to cardiac geomet...
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ژورنال
عنوان ژورنال: Journal of Hypertension
سال: 2010
ISSN: 0263-6352
DOI: 10.1097/hjh.0b013e328339fd3a